Mold Resource Glossary
Molds are organized into three main classifications based on their subsequent human responses:
Allergenic Molds: Allergenic molds are not typically considered life-threatening
and are most likely to affect those who are already allergic or asthmatic. The human
system responses to allergenic molds tend to be relatively mild, typically producing
sore or scratchy throats, eye and nose irritations and rashes.
Pathogenic Molds: Pathogenic molds tend to be associated with some
type of infection. Those who suffer from a more suppressed immune system are mostly
likely to experience more sever heath effects from these molds. Healthy people can
usually naturally resist infection. In rare cases, high exposure may cause hypersensitivity
pneumonitis (an acute response to exposure to an organism.
Toxigenic Molds: Of the three, toxigenic molds can cause the most
serious health effects. Mycotoxins have toxic effects ranging from short-term irritation
to immunosuppression and possibly cancer. Therefore, when toxigenic molds are found,
immediate evaluation is recommended.
Absidia sp - A zygomycete fungus which
is considered common to the indoor environment. Reported to be allergenic. May cause
mucorosis in immune compromised individuals. The sites of infection are the lung,
nasal sinus, brain, eye, and skin. Infection may have multiple sites. Absidia cormbifera
has been an invasive infection agent in AIDS and neutropenic patients, as well as,
agents of bovine mycotic abortions, and feline subcutaneous abscesses. Acremonium
species may be confused with Fusarium species that primarily produce microconidia
in culture. Fusarium genera are generally much more rapid growers and produce more
aerial mycelium. |
Acremonium sp (Cephalosporium sp.)
- Reported to be allergenic. Can produce a trichothecene toxin which is toxic if
ingested. It was the primary fungus identified in at least two houses where the
occupant complaints were nausea, vomiting, and diarrhea. Asexual state of Emericellopsis
sp., Chaetomium sp., and Nectripsis sp. It can produce mycetomas, infections of
the nails, onychomycosis, corneal ulcers, eumycotic mycetoma, endophthalmitis, meningitis,
and endocarditis. |
Alternaria sp - Extremely widespread
and ubiquitous. Outdoors it may be isolated from samples of soil, seeds, and plants.
It is commonly found in outdoor samples. It is often found in carpets, textiles,
and on horizontal surfaces in building interiors. Often found on window frames.
The species Alternaria alternata is capable of producing tenuazonic acid and other
toxic metabolites which may be associated with disease in humans or animals. Alternaria
produces large spores having sizes between 20 - 200 microns in length and 7 - 18
microns in width, suggesting that the spores from this fungi are deposited in the
nose, mouth, and upper respiratory tract. It may be related to bakers asthma. It
has been associated with hypersensitivity pneumoniti, sinusitis, deratomycosis,
onychomycosis, subcutaneous phaeohyphomycosis, and invasive infection. Common cause
of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms include
edema and bronchiospasms, chronic cases may develop pulmonary emphysema. |
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Ascomycete.- One of the major classes
of fungal organisms. This class contains the the"sac fungi" and yeasts.
Some ascomycete spores can be identified by spore morphology, however; some care
should be excersised with regard to specific identification. Many ascomycete spores
are reported to be allergenic. |
Aspergillus sp - A genus of fungi
containing approximately 150 recognized species. Members of this genus have been
recovered from a variety of habitats, but are especially common as saprophytes on
decaying vegetation, soils, stored food, feed products in tropical and subtropical
regions. Some species are parasitic on insects, plants and animals, including man.
Species within this genus have reported Aw's (water activities) between 0.75 - 0.82.
All of the species contained in this genus should be considered allergenic. Various
Aspergillus species are a common cause of extrinsic asthma (immediate-type hypersensitivity:
type I). Acute symptoms include edema and bronchiospasms. Chronic cases may develop
pulmonary emphysema. Members of this genus are reported to cause a variety of opportunistic
infections of the ears and eyes. Sever pulmonary infections may also occur. Many
species produce mycotoxins which may be associated with disease in humans and other
animals. Toxin production is dependent on the species or a strain within a species
and on the food source for the fungus. Some of these toxins have been found to be
carcinogenic in animal species. Several toxins are considered potential human carcinogens. |
Aureobasidium
pullulans - A cosmopolitan fungus with the main habitat apparently on the
aerial parts of plants. Frequently found in moist environments. This fungus should
be considered allergenic. This species has been associated with deratitis, peritonitis,
pulmaonary infection, and invasive disease in AIDS patients. Probably aquired by
traumatic implantation. May be recovered as a contaminant from human cutaneous sites.
No toxic diseases have been documented to date. |
Basidiomycetes
- One of the major classes of fungal organisms. This class contains the mushrooms,
shelf fungi, puffballs, and a variety of other macrofungi. It is extremely difficult
to identify a specific genera of mushrooms by using standard culture plate techniques.
Some basidiomycete spores can be identified by spore morphology, however; some care
should be exercised with regard to specific identification. Many basidiomycete spores
are reported to be allergenic. |
Bipolaris sp - A widespread fungus
that is most frequently associated with grasses, plant material, decaying food,
and soil. It is common to both indoor and outdoor environments. Older obsolete names
include Drechslera and Helminthosporium. This fungus produces large spores which
would be expected to be deposited in the upper respiratory tract. Various species
of this fungus can produce the mycotoxin - sterigmatocystin which has been shown
to produce liver and kidney damage when ingested by laboratory animals. |
Candida sp - Candida is a genus of
yeasts. Many species of this genus are endosymbionts of animal hosts including humans.
While usually living as commensals, some Candida species have the potential to cause
disease. Clinically, the most significant member of the genus is Candida albicans,
which can cause infections (called candidiasis or thrush) in humans and other animals,
especially in immunocompromised patients.
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Chaetomium sp. - Large ascomycetous
fungus producing perithecia. It is found on a variety of substrates containing cellulose
including paper and plant compost. It can be readily found on the damp or water
damaged paper in sheetrock. |
Chrysosporium spp
- Widespread, common in the soil and on plants. Rare agents of onychomycosis, skin
lesions, endocarditis, and uncommon agents of the pulmonary mycosis adiaspiromycosis.
No toxic diseases have been documented to date. |
Cladosporium sp. (Hormodendrum
sp.) - Aw (water activity) in the range of 0.84 to 0.88. Most commonly
identified outdoor fungus. The outdoor numbers are reduced in the winter. The numbers
are often high in the summer. Often found indoors in numbers less than outdoor numbers.
It is a common allergen. Indoor Cladosporium sp. may be different than the species
identified outdoors. It is commonly found on the surface of fiberglass duct liner
in the interior of supply ducts. A wide variety of plants are food sources for this
fungus. It is found on dead plants, woody plants, food, straw, soil, paint and textiles.
It can cause mycosis. Produces greater than 10 antigens. Antigens in commercial
extracts are of variable quality and may degrade within weeks of preparation. Common
cause of extrinsic asthma (immediate-type hypersensitivity: type I). Acute symptoms
include edema and bronchiospasms, chronic cases may develop pulmonary emphysema. |
Curvularia sp. - Curvularia is a hyphomycete
(mold) fungus which is a facultative pathogen of many plant species and of the soil.
Curvularia lunata appears as shiny velvety-black, fluffy growth on the colony surface. Reported to be allergenic. It may cause corneal infections, mycetoma and infections in immune compromised hosts. |
Dreschlera sp - Drechslera is a genus
of fungi. Many of the species in this genus are plant pathogens. Conidia (spores)
dimensions 40-120 x 17-28 microns. Found on grasses, grains and decaying food. It
can occasionally cause a corneal infection of the eye. |
Epicoccum sp. - Epicoccum nigrum is
a species of fungus. A plant pathogen, it is widespread fungus which produces colored
pigments that can be used as antifungal agents against other pathogenic fungi. Conidia
(spores) dimensions 15-25 microns. A common allergen. It is found in plants, soil,
grains, textiles, and paper products. |
Fusarium sp - Aw (water activity)
0.90. A common soil fungus. It is found on a wide range of plants. It is often found
in humidifiers. Several species in this genus can produce potent trichothecene toxins
(5, 27). The trichothecene (scirpene) toxin targets the following systems: circulatory,
alimentary, skin, and nervous. Produces vomitoxin on grains during unusually damp
growing conditions. Symptoms may occur either through ingestion of contaminated
grains or possibly inhalation of spores. The genera can produce hemorrhagic syndrome
in humans (alimentary toxic aleukia). This is characterized by nausea, vomiting,
diarrhea, dermatitis, and extensive internal bleeding. Reported to be allergenic.
Frequently involved in eye, skin and nail infections. |
Geotrichum sp. - Aw (water activity)
0.90. Conidia (spores) dimensions 6-12 x 3-6 microns. Aw (water activity) 0.90.
A common contaminant of grains, fruits, dairy products, paper, textiles, soil and
water, and often present as part of the normal human flora. The species Geotrichum
candidum can cause a secondary infection (geotrichosis) in association with tuberculosis.
This rare disease can cause lesions of the skin, bronchi, mouth, lung, and intestine. |
Mucor sp. - Often found in soil, dead
plant material, horse dung, fruits, and fruit juice. It is also found in leather,
meat, dairy products, animal hair, and jute. A Zygomycetes fungus which may be allergenic
(skin and bronchial tests) (7, 17). This organism and other Zygomycetes will grow
rapidly on most fungal media. May cause mucorosis in immune compromised individuals.
The sites of infection are the lung, nasal sinus, brain, eye, and skin. Infection
may have multiple sites. |
Nigrospora sp - Nigrospora sp. is
generally found in decaying plant material and soil. The most common health effects
seen from these spores are allergenic effects displayed as Type I allergies. There
are no known toxins at this time. |
Paecilomyces sp
- Commonly found in soil and dust, less frequently in air. P. variotii can cause
paecilomycosis. Linked to wood-trimmers disease and humidifier associated illnesses.
They are reported to allergenic. Some members of this genus are reported to cause
pneumonia. It may produce arsine gas if growing on arsenic substrate. This can occur
on wallpapers covered with paris green. |
Papulospora sp. - This fungi is found
in soil, textiles, decaying plants, manure, and paper. |
Penicillium sp - Aw (water activity)
0.78 - 0.88. A wide number of organisms have placed in this genera. Identification
to species is difficult. Often found in aerosol samples. Commonly found in soil,
food, cellulose, and grains (17, 5). It is also found in paint and compost piles.
It may cause hypersensitivity pneumonitis and allergic alveolitis in susceptible
individuals. It is reported to be allergenic (skin) (7, 17). It is commonly found
in carpet, wallpaper, and in interior fiberglass duct insulation (NC). Some species
can produce mycotoxins. Common cause of extrinsic asthma (immediate-type hypersensitivity:
type I). Acute symptoms include edema and bronchiospasms, chronic cases may develop
pulmonary emphysema. |
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Phoma sp. - A common indoor air allergen.
It is similar to the early stages of growth of Chaetomium sp. The species are isolated
from soil and associated plants (particularly potatoes). Produces pink and purple
spots on painted walls (3, 17). It may have antigens which cross-react with those
of Alternaria sp. It will grow on butter, paint, cement, and rubber. It may cause
phaeohyphomycosis, a systematic or subcutaneous disease. |
Pithomyces sp. - Grows on dead grass
in pastures. Causes facial eczema in ruminants. |
Rhizomucor sp. - The Zygomycetous
fungus is reported to be allergenic. It may cause mucorosis in immune compromised
individuals. It occupies a biological niche similar to Mucor sp. It is often linked
to occupational allergy. The sites of infection are the lung, nasal sinus, brain,
eye, and skin. Infection may have multiple sites. |
Rhizopus sp - The Zygomycetous fungus
is reported to be allergenic. It may cause mucorosis in immune compromised individuals.
It occupies a biological niche similar to Mucor sp. It is often linked to occupational
allergy. The sites of infection are the lung, nasal sinus, brain, eye, and skin.
Infection may have multiple sites. |
Rhodotorula sp - A reddish yeast typically
found in moist environments such as carpeting, cooling coils, and drain pans. In
some countries it is the most common yeast genus identified in indoor air. This
yeast has been reported to be allergenic. Positive skin tests have been reported.
It has colonized in terminally ill patients. Sporotrichum sp - Reported to be allergenic.
See also Sporothrix sp. as there is some taxonomic confusion between these two genera.
This genera does not cause sporotrichosis. |
Stachybotrys sp.
- Aw (water activity) - 0.94, optimum Aw (water activity) - >0.98. Several strains
of this fungus (S. atra, S. chartarum and S. alternans are synonymous) may produce
a trichothecene mycotoxin- Satratoxin H - which is poisonous by inhalation. The
toxins are present on the fungal spores. This is a slow growing fungus on media.
It does not compete well with other rapidly growing fungi. The dark colored fungi
grows on building material with a high cellulose content and a low nitrogen content.
Areas with relative humidity above 55% and are subject to temperature fluctuations
are ideal for toxin production. Individuals with chronic exposure to the toxin produced
by this fungus reported cold and flu symptoms, sore throats, diarrhea, headaches,
fatigue, dermatitis, intermittent local hair loss, and generalized malaise. The
toxins produced by this fungus will suppress the immune system affecting the lymphoid
tissue and the bone marrow. Animals injected with the toxin from this fungus exhibited
the following symptoms: necrosis and hemorrhage within the brain, thymus, spleen,
intestine, lung, heart, lymph node, liver, and kidney. The mycotoxin is also reported
to be a liver and kidney carcinogen. Affects by absorption of the toxin in the human
lung are known as pneumomycosis. This organism is rarely found in outdoor samples.
It is usually difficult to find in indoor air samples unless it is physically disturbed.
The spores are in a gelatinous mass. Appropriate media for the growth of this organism
will have a high cellulose content and a low nitrogen content. The spores will die
readily after release. The dead spores are still allergenic and toxigenic. Percutaneous
absorption has caused mild symptoms. |
Stemphylium sp. - Reported to be allergenic.
Isolated from dead plants and cellulose materials. |
Syncephalastrum sp.
- Can cause a respiratory infection characterized by a solid fungal ball. |
Trichoderma sp - It is commonly found
in soil, dead trees, pine needles, paper, and unglazed ceramics. It often will grow
on other fungi. It produces antibiotics which are toxic to humans. It has been reported
to be allergenic (7, 17). It readily degrades cellulose. |
Trichophyton sp
- Can cause ring worm, athlete's foot, skin, nail, beard, and scalp. Reported to
be allergenic. Found on soil and skin. |
Ulocladium sp - Has an Aw (water activity)
of 0.89. Isolated from dead plants and cellulose materials. Found on textiles. |
Verticillium sp
- Conidia (spores) dimensions 2.3-10 x 1-2.6 microns. Found in decaying vegetation,
on straw, soil, and arthropods. A rare cause of corneal infections.
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Wallemia sp - Has an Aw (water activity)
of 0.75. Conidia (spores) dimensions 2.5-3.5 microns. Found in sugary foods, salted
meats, dairy products, textiles, soil, hay, and fruits. |
Yeast - Various yeasts are commonly
identified on air samples. Some yeasts are reported to be allergenic. They may cause
problems if a person has had previous exposure and developed hypersensitivity. Yeasts
may be allergenic to susceptible individuals when present in sufficient concentrations.
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